hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1142 |
6. Filter based on genotype QC (FinnGen only) |
1015 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12357 | 6434 | 5535 |
| Only index persons | 8979 | 4855 | 4124 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.18 | 0.15 |
| Only index persons | 0.17 | 0.18 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 51.74 | 53.46 | 50.94 |
| Only index persons | 47.59 | 47.37 | 47.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1015 | 513 | 502 |
| Unadjusted period prevalence (%) | 0.23 | 0.20 | 0.25 |
| Median age at first event (years) | 57.40 | 52.39 | 62.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_HAEMOLYTICANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMOLYTICANAEMIA | 2.473 [2.14, 2.85] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 1256 out of 4383 females with D3_HAEMOLYTICANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMOLYTICANAEMIA | 2.749 [2.33, 3.24] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1102 out of 3793 males with D3_HAEMOLYTICANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_HAEMOLYTICANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.505% |
| 5 | 1.307% | 3.3% |
| 10 | 3.425% | 7.845% |
| 15 | 6.329% | 14.152% |
| 20 | 10.539% | 23.642% |
Relationships between endpoints
↥Index endpoint: D3_HAEMOLYTICANAEMIA – Haemolytic anaemias
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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