obsolete_sickle cell disease: ['A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
77 |
4. Check minimum number of eventsNone |
77 |
5. Include endpointsNone |
77 |
6. Filter based on genotype QC (FinnGen only) |
63 |
Control definitions (FinnGen only)
Control exclude
D3_HAEMOLYTICANAEMIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D55-D59
Name in latin
Morbi meniscocytici
Similar endpoints
↥List of similar endpoints to
Sickle-cell disorders
based on the number of shared cases.
Similar with more cases:
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 754 | 385 | 332 |
| Only index persons | 575 | 317 | 258 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.37 | 54.03 | 52.53 |
| Only index persons | 56.62 | 57.36 | 55.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 63 | 33 | 30 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 60.12 | 60.19 | 60.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_SICKLECELLDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SICKLECELLDIS | 1.674 [1.26, 2.22] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 347 females with D3_SICKLECELLDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SICKLECELLDIS | 2.204 [1.57, 3.09] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 302 males with D3_SICKLECELLDIS died.
Mortality risk
Mortality risk for people of age
years, who have D3_SICKLECELLDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.379% |
| 5 | 0.85% | 2.853% |
| 10 | 2.005% | 6.648% |
| 15 | 3.874% | 12.489% |
| 20 | 6.564% | 20.377% |
Relationships between endpoints
↥Index endpoint: D3_SICKLECELLDIS – Sickle-cell disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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