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Other and unspecified acquired haemolytic anaemias

DOID EFO Endpoint Browser PheWeb

D3_ACQHAEMOLYTICANAEMIANAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D59.8, D59.9
  • Hospital discharge: ICD-9 — 283[2-9]
  • Hospital discharge: ICD-8 — 2830|28398
  • Hospital discharge: excluded ICD-9 — 2832B|2832C
  • Cause of death: ICD-10 — D59.8, D59.9
  • Cause of death: ICD-9 — 283[2-9]
  • Cause of death: ICD-8 — 2830|28398
  • Cause of death: excluded ICD-9 — 2832B|2832C

2 out of 7 registries used, show all original rules.

295

4. Check minimum number of events

None

295

5. Include endpoints

None

295

6. Filter based on genotype QC (FinnGen only)

284

Control definitions (FinnGen only)

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3078 1682 1353
Only index persons 1978 1086 892
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 66.16 67.62 64.26
Only index persons 61.66 62.26 60.92

-FinnGen-

Key figures

All Female Male
Number of individuals 284 129 155
Unadjusted period prevalence (%) 0.07 0.05 0.08
Median age at first event (years) 62.10 55.04 67.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_ACQHAEMOLYTICANAEMIANAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_ACQHAEMOLYTICANAEMIANAS 3.114 [2.46, 3.95] < 0.001
Birth year 0.992 [0.98, 1.0] 0.071

During the follow-up period (1.1.1998 — 31.12.2019), 453 out of 959 females with D3_ACQHAEMOLYTICANAEMIANAS died.

Males

Parameter HR [95% CI] p-value
D3_ACQHAEMOLYTICANAEMIANAS 3.138 [2.33, 4.22] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 359 out of 817 males with D3_ACQHAEMOLYTICANAEMIANAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_ACQHAEMOLYTICANAEMIANAS.

N-year risk Females Males
1 0.352% 0.488%
5 1.783% 3.256%
10 4.076% 7.853%
15 7.3% 14.352%
20 12.566% 23.308%

Relationships between endpoints

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Index endpoint: D3_ACQHAEMOLYTICANAEMIANAS – Other and unspecified acquired haemolytic anaemias

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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