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Other autoimmune haemolytic anaemias

DOID EFO Endpoint Browser PheWeb

D3_AIHA_OTHER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D59.1
  • Hospital discharge: ICD-9 — 2830
  • Hospital discharge: ICD-8 — 28390
  • Hospital discharge: excluded ICD-9 — 2830B
  • Cause of death: ICD-10 — D59.1
  • Cause of death: ICD-9 — 2830
  • Cause of death: ICD-8 — 28390
  • Cause of death: excluded ICD-9 — 2830B

2 out of 7 registries used, show all original rules.

363

4. Check minimum number of events

None

363

5. Include endpoints

None

363

6. Filter based on genotype QC (FinnGen only)

348

Control definitions (FinnGen only)

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D59
Name in latin Aliae anaemiae autoimmunes haemolyticae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3078 1652 1390
Only index persons 2344 1276 1068
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 68.37 69.80 66.65
Only index persons 67.43 68.54 66.11

-FinnGen-

Key figures

All Female Male
Number of individuals 348 175 173
Unadjusted period prevalence (%) 0.08 0.07 0.09
Median age at first event (years) 63.82 60.34 67.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_AIHA_OTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_AIHA_OTHER 2.299 [1.91, 2.77] < 0.001
Birth year 1.0 [0.99, 1.01] 0.982

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1170 females with D3_AIHA_OTHER died.

Males

Parameter HR [95% CI] p-value
D3_AIHA_OTHER 2.82 [2.2, 3.62] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 976 males with D3_AIHA_OTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_AIHA_OTHER.

N-year risk Females Males
1 0.296% 0.505%
5 1.48% 3.21%
10 3.848% 8.18%
15 7.384% 13.968%
20 13.26% 22.862%

Relationships between endpoints

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Index endpoint: D3_AIHA_OTHER – Other autoimmune haemolytic anaemias

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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