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Other and unspecified anaemias

DOID EFO Endpoint Browser PheWeb

D3_ANAEMIANAS

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D64.8, D64.9
  • Hospital discharge: ICD-9 — 285[8-9]
  • Hospital discharge: ICD-8 — 285[8-9]
  • Cause of death: ICD-10 — D64.8, D64.9
  • Cause of death: ICD-9 — 285[8-9]
  • Cause of death: ICD-8 — 285[8-9]

2 out of 7 registries used, show all original rules.

17490

4. Check minimum number of events

None

17490

5. Include endpoints

None

17490

6. Filter based on genotype QC (FinnGen only)

16799

Control definitions (FinnGen only)

Control exclude D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 175844 95683 78180
Only index persons 137521 76274 61247
Unadjusted period prevalence (%)
Whole population 2.49 2.74 2.18
Only index persons 2.60 2.80 2.34
Median age at first event (years)
Whole population 73.15 74.61 71.38
Only index persons 72.17 73.31 70.76

-FinnGen-

Key figures

All Female Male
Number of individuals 16799 7865 8934
Unadjusted period prevalence (%) 3.83 3.09 4.49
Median age at first event (years) 69.32 66.44 71.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint D3_ANAEMIANAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_ANAEMIANAS 2.371 [2.15, 2.61] < 0.001
Birth year 0.993 [0.99, 1.0] 0.059

During the follow-up period (1.1.1998 — 31.12.2019), 37421 out of 73730 females with D3_ANAEMIANAS died.

Males

Parameter HR [95% CI] p-value
D3_ANAEMIANAS 3.027 [2.68, 3.41] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 33017 out of 59788 males with D3_ANAEMIANAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_ANAEMIANAS.

N-year risk Females Males
1 0.165% 0.513%
5 1.199% 2.929%
10 2.931% 7.462%
15 5.489% 13.64%
20 9.059% 21.678%

Relationships between endpoints

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Index endpoint: D3_ANAEMIANAS – Other and unspecified anaemias

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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