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Drug-induced autoimmune haemolytic anaemia

DOID EFO Endpoint Browser

D3_AIHA_DRUG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D59.0#
  • Hospital discharge: ICD-9 — 2830B
  • Hospital discharge: ICD-8 — 28391
  • Cause of death: ICD-10 — D59.0#
  • Cause of death: ICD-9 — 2830B
  • Cause of death: ICD-8 — 28391

2 out of 7 registries used, show all original rules.

43

4. Check minimum number of events

None

43

5. Include endpoints

None

43

6. Filter based on genotype QC (FinnGen only)

42

Control definitions (FinnGen only)

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D59
Name in latin Anaemia autoimmunis haemolytica medicamentis provocata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 547 318 222
Only index persons 353 208 145
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 61.21 62.60 59.20
Only index persons 53.14 57.03 47.57

-FinnGen-

Key figures

All Female Male
Number of individuals 42 25 17
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 57.41 55.79 59.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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Association

Association between endpoint D3_AIHA_DRUG and mortality.

Females

Parameter HR [95% CI] p-value
D3_AIHA_DRUG 2.793 [1.83, 4.26] < 0.001
Birth year 0.991 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 199 females with D3_AIHA_DRUG died.

Males

Parameter HR [95% CI] p-value
D3_AIHA_DRUG 3.119 [1.76, 5.53] < 0.001
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 146 males with D3_AIHA_DRUG died.

Mortality risk

Mortality risk for people of age

years, who have D3_AIHA_DRUG.

N-year risk Females Males
1 0.302% 0.613%
5 1.661% 3.818%
10 3.544% 9.049%
15 6.681% 16.557%
20 11.785% 27.62%

Relationships between endpoints

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Index endpoint: D3_AIHA_DRUG – Drug-induced autoimmune haemolytic anaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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