Haemolytic-uraemic syndrome

D3_NONAIHA_OTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D59.3
  • Hospital discharge: ICD-9 2831C
  • Cause of death: ICD-10 D59.3
  • Cause of death: ICD-9 2831C

2 out of 7 registries used, show all original rules.

81

4. Check minimum number of events

None

81

5. Include endpoints

None

81

6. Filter based on genotype QC (FinnGen only)

77

Control definitions (FinnGen only)

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D59
Name in latin Syndroma haemolytico-uraemicum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 569 325 242
Only index persons 445 258 187
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 25.46 26.20 24.21
Only index persons 25.69 26.59 24.44

-FinnGen-

Key figures

All Female Male
Number of individuals 77 43 34
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 39.21 31.69 48.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint D3_NONAIHA_OTHER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_NONAIHA_OTHER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_NONAIHA_OTHER – Haemolytic-uraemic syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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