hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
54 |
4. Check minimum number of eventsNone |
54 |
5. Include endpointsNone |
54 |
6. Filter based on genotype QC (FinnGen only) |
52 |
Control definitions (FinnGen only)
Control exclude
D3_HAEMOLYTICANAEMIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D59
Name in latin
Aliae anaemiae non autoimmunes haemolyticae
Similar endpoints
↥List of similar endpoints to
Other nonautoimmune haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 438 | 222 | 207 |
| Only index persons | 286 | 140 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.19 | 68.72 | 61.30 |
| Only index persons | 61.49 | 62.70 | 60.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 52 | 28 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 65.12 | 68.72 | 60.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_NOCT_HAEMOGLOBINURIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NOCT_HAEMOGLOBINURIA | 2.556 [1.24, 5.26] | 0.011 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 139 females with D3_NOCT_HAEMOGLOBINURIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NOCT_HAEMOGLOBINURIA | 3.81 [2.25, 6.45] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 138 males with D3_NOCT_HAEMOGLOBINURIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_NOCT_HAEMOGLOBINURIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.305% | 0.681% |
| 5 | 1.497% | 4.41% |
| 10 | 3.57% | 10.283% |
| 15 | 6.782% | 17.758% |
| 20 | 11.725% | 28.367% |
Relationships between endpoints
↥Index endpoint: D3_NOCT_HAEMOGLOBINURIA – Other nonautoimmune haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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