No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
21285 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4115 |
6. Filter based on genotype QC (FinnGen only) |
3996 |
Control definitions (FinnGen only)
Control conditions
not J10_COPDNAS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
COPD-related respiratory insufficiency
based on the number of shared cases.
Similar with more cases:
- COPD, early/later onset
- Other chronic obstructive pulmonary disease
- COPD
- Other chronic obstructive pulmonary disease , including avohilmo
- Chronic lower respiratory diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30357 | 10179 | 19634 |
| Only index persons | 22108 | 8032 | 14076 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.46 | 0.29 | 0.55 |
| Only index persons | 0.45 | 0.30 | 0.54 |
| Median age at first event (years) | |||
| Whole population | 70.82 | 70.93 | 70.75 |
| Only index persons | 70.60 | 70.78 | 70.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3996 | 1116 | 2880 |
| Unadjusted period prevalence (%) | 1.16 | 0.44 | 1.45 |
| Median age at first event (years) | 71.13 | 68.14 | 72.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint COPD_INSUFFICIENCY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| COPD_INSUFFICIENCY | 7.189 [6.29, 8.22] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.291 |
During the follow-up period (1.1.1998 — 31.12.2019), 4637 out of 7596 females with COPD_INSUFFICIENCY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| COPD_INSUFFICIENCY | 5.878 [5.05, 6.84] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 9064 out of 14020 males with COPD_INSUFFICIENCY died.
Mortality risk
Mortality risk for people of age
years, who have COPD_INSUFFICIENCY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.727% | 1.087% |
| 5 | 4.208% | 6.526% |
| 10 | 9.328% | 16.135% |
| 15 | 17.705% | 27.548% |
| 20 | 30.526% | 42.135% |
Relationships between endpoints
↥Index endpoint: COPD_INSUFFICIENCY – COPD-related respiratory insufficiency
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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