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Secondary right heart disease

DOID EFO Endpoint Browser PheWeb

I9_SECONDRIGHT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I27
  • Hospital discharge: ICD-9 — 416
  • Hospital discharge: ICD-8 — 426
  • Cause of death: ICD-10 — I27
  • Cause of death: ICD-9 — 416
  • Cause of death: ICD-8 — 426

2 out of 7 registries used, show all original rules.

1341

4. Check minimum number of events

None

1341

5. Include endpoints

None

1341

6. Filter based on genotype QC (FinnGen only)

1298

Control definitions (FinnGen only)

Control exclude I9_PULMHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 I26-I28
Name in latin Aliae morbi cordis pulmonales

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13969 6378 7264
Only index persons 7983 4349 3634
Unadjusted period prevalence (%)
Whole population 0.20 0.18 0.20
Only index persons 0.15 0.16 0.14
Median age at first event (years)
Whole population 70.65 71.85 69.68
Only index persons 72.86 74.08 71.39

-FinnGen-

Key figures

All Female Male
Number of individuals 1298 598 700
Unadjusted period prevalence (%) 0.30 0.23 0.35
Median age at first event (years) 70.50 68.92 71.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_SECONDRIGHT and mortality.

Females

Parameter HR [95% CI] p-value
I9_SECONDRIGHT 4.26 [3.59, 5.05] < 0.001
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 1966 out of 3567 females with I9_SECONDRIGHT died.

Males

Parameter HR [95% CI] p-value
I9_SECONDRIGHT 5.409 [4.32, 6.77] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1936 out of 3007 males with I9_SECONDRIGHT died.

Mortality risk

Mortality risk for people of age

years, who have I9_SECONDRIGHT.

N-year risk Females Males
1 0.316% 0.847%
5 2.129% 5.453%
10 4.79% 12.918%
15 10.15% 23.045%
20 17.095% 36.926%

Relationships between endpoints

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Index endpoint: I9_SECONDRIGHT – Secondary right heart disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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