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Hypertension, Pulmonary Arterial

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSPUL

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I27.0
  • Hospital discharge: ICD-9 — 4160A
  • Hospital discharge: ICD-8 — 42600
  • Cause of death: ICD-10 — I27.0
  • Cause of death: ICD-9 — 4160A
  • Cause of death: ICD-8 — 42600

2 out of 7 registries used, show all original rules.

291

4. Check minimum number of events

None

291

5. Include endpoints

None

291

6. Filter based on genotype QC (FinnGen only)

277

Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I27
Name in latin Hypertensio pulmonalis primaria

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2950 1579 1316
Only index persons 1759 1100 659
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 65.26 67.03 63.32
Only index persons 68.00 69.52 65.46

-FinnGen-

Key figures

All Female Male
Number of individuals 277 183 94
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 60.40 58.79 63.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint I9_HYPTENSPUL and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPTENSPUL 4.18 [3.33, 5.24] < 0.001
Birth year 0.994 [0.99, 1.0] 0.19

During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1066 females with I9_HYPTENSPUL died.

Males

Parameter HR [95% CI] p-value
I9_HYPTENSPUL 4.585 [3.19, 6.59] < 0.001
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 390 out of 643 males with I9_HYPTENSPUL died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPTENSPUL.

N-year risk Females Males
1 0.421% 0.888%
5 2.404% 5.63%
10 6.259% 13.925%
15 11.562% 25.475%
20 19.153% 39.831%

Relationships between endpoints

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Index endpoint: I9_HYPTENSPUL – Hypertension, Pulmonary Arterial

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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