No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
8970 |
4. Check minimum number of eventsNone |
8970 |
5. Include endpointsNone |
8970 |
6. Filter based on genotype QC (FinnGen only) |
8663 |
Control definitions (FinnGen only)
Control exclude
ILD_COMORB
Extra metadata
First used in FinnGen datafreeze
DF2
Continuous positive airway pressure
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 62273 | 23857 | 38134 |
| Only index persons | 45606 | 16596 | 29010 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.92 | 0.68 | 1.07 |
| Only index persons | 0.93 | 0.61 | 1.11 |
| Median age at first event (years) | |||
| Whole population | 57.66 | 59.07 | 56.68 |
| Only index persons | 62.08 | 64.84 | 60.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8663 | 3333 | 5330 |
| Unadjusted period prevalence (%) | 2.15 | 1.31 | 2.68 |
| Median age at first event (years) | 63.30 | 62.19 | 64.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CPAP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CPAP | 3.242 [2.82, 3.73] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.398 |
During the follow-up period (1.1.1998 — 31.12.2019), 3807 out of 20443 females with CPAP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CPAP | 2.609 [2.26, 3.01] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 5627 out of 33117 males with CPAP died.
Mortality risk
Mortality risk for people of age
years, who have CPAP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.307% | 0.48% |
| 5 | 2.055% | 2.949% |
| 10 | 4.78% | 7.29% |
| 15 | 9.292% | 13.455% |
| 20 | 15.925% | 22.439% |
Relationships between endpoints
↥Index endpoint: CPAP – Continuous positive airway pressure
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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