No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
9109 |
4. Check minimum number of eventsNone |
9109 |
5. Include endpointsNone |
9109 |
6. Filter based on genotype QC (FinnGen only) |
8807 |
Control definitions (FinnGen only)
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 58733 | 29661 | 28938 |
Only index persons | 52671 | 27189 | 25482 |
Unadjusted period prevalence (%) | |||
Whole population | 0.83 | 0.85 | 0.81 |
Only index persons | 0.99 | 1.00 | 0.97 |
Median age at first event (years) | |||
Whole population | 56.59 | 55.71 | 57.58 |
Only index persons | 59.72 | 58.37 | 61.17 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 8807 | 4820 | 3987 |
Unadjusted period prevalence (%) | 1.94 | 1.89 | 2.00 |
Median age at first event (years) | 62.80 | 59.58 | 66.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint NIV and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
NIV | 4.582 [2.97, 7.06] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 1178 out of 17147 females with NIV died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
NIV | 4.277 [2.76, 6.63] | < 0.001 |
Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 1616 out of 16769 males with NIV died.
Mortality risk
Mortality risk for people of age
years, who have NIV.N-year risk | Females | Males |
---|---|---|
1 | 0.494% | 0.614% |
5 | 2.311% | 4.741% |
10 | 5.81% | 12.112% |
15 | 10.205% | 21.628% |
20 | 18.033% | 34.608% |
Relationships between endpoints
↥Index endpoint: NIV – Non-invasive ventilation
GWS hits: -