Non-invasive ventilation

NIV

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Operations: NOMESCO codes ^WX725

1 out of 7 registries used, show all original rules.

9109

4. Check minimum number of events

None

9109

5. Include endpoints

None

9109

6. Filter based on genotype QC (FinnGen only)

8807

Control definitions (FinnGen only)

Control exclude ILD_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 58733 29661 28938
Only index persons 52671 27189 25482
Unadjusted period prevalence (%)
Whole population 0.83 0.85 0.81
Only index persons 0.99 1.00 0.97
Median age at first event (years)
Whole population 56.59 55.71 57.58
Only index persons 59.72 58.37 61.17

-FinnGen-

Key figures

All Female Male
Number of individuals 8807 4820 3987
Unadjusted period prevalence (%) 1.94 1.89 2.00
Median age at first event (years) 62.80 59.58 66.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint NIV and mortality.

Females

Parameter HR [95% CI] p-value
NIV 4.582 [2.97, 7.06] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 1178 out of 17147 females with NIV died.

Males

Parameter HR [95% CI] p-value
NIV 4.277 [2.76, 6.63] < 0.001
Birth year 0.988 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 1616 out of 16769 males with NIV died.

Mortality risk

Mortality risk for people of age

years, who have NIV.

N-year risk Females Males
1 0.494% 0.614%
5 2.311% 4.741%
10 5.81% 12.112%
15 10.205% 21.628%
20 18.033% 34.608%

Relationships between endpoints

Index endpoint: NIV – Non-invasive ventilation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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