No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
2528 |
4. Check minimum number of eventsNone |
2528 |
5. Include endpointsNone |
2528 |
6. Filter based on genotype QC (FinnGen only) |
2416 |
Control definitions (FinnGen only)
Control exclude
COPD_INSUFFICIENCY
Extra metadata
First used in FinnGen datafreeze
DF2
Invasive ventilation
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 25367 | 9923 | 15221 |
| Only index persons | 19618 | 7776 | 11842 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.37 | 0.28 | 0.43 |
| Only index persons | 0.39 | 0.29 | 0.45 |
| Median age at first event (years) | |||
| Whole population | 59.98 | 59.89 | 59.96 |
| Only index persons | 62.22 | 62.50 | 62.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2416 | 989 | 1427 |
| Unadjusted period prevalence (%) | 0.58 | 0.39 | 0.72 |
| Median age at first event (years) | 63.05 | 59.22 | 65.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint INV_VENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| INV_VENT | 5.323 [4.52, 6.27] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 1935 out of 6835 females with INV_VENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| INV_VENT | 5.075 [4.37, 5.89] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3468 out of 10146 males with INV_VENT died.
Mortality risk
Mortality risk for people of age
years, who have INV_VENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.509% | 0.916% |
| 5 | 2.475% | 5.381% |
| 10 | 6.644% | 12.904% |
| 15 | 12.336% | 22.399% |
| 20 | 20.436% | 34.488% |
Relationships between endpoints
↥Index endpoint: INV_VENT – Invasive ventilation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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