pneumonia: An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, caused by an infection in one or both of the lungs (by bacteria, viruses, fungi, or mycoplasma.). Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
54128 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
15329 |
6. Filter based on genotype QC (FinnGen only) |
14763 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_INFECTIONS
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma-related pneumonia
based on the number of shared cases.
Similar with more cases:
- Asthma-related pneumonia or sepsis
- Asthma, hospital admissions 3, pneumonia
- Asthma-related infections
- Asthma, hospital admission 2, infections
- Asthma
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 149546 | 76459 | 71699 |
| Only index persons | 120997 | 64203 | 56794 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.09 | 2.19 | 2.00 |
| Only index persons | 2.27 | 2.36 | 2.17 |
| Median age at first event (years) | |||
| Whole population | 62.91 | 65.53 | 59.96 |
| Only index persons | 59.79 | 63.39 | 55.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14763 | 7661 | 7102 |
| Unadjusted period prevalence (%) | 3.28 | 3.01 | 3.57 |
| Median age at first event (years) | 60.59 | 56.29 | 65.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_PNEUMONIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_PNEUMONIA | 2.303 [2.08, 2.55] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.252 |
During the follow-up period (1.1.1998 — 31.12.2019), 19174 out of 52922 females with ASTHMA_PNEUMONIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_PNEUMONIA | 2.425 [2.17, 2.71] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 17455 out of 46042 males with ASTHMA_PNEUMONIA died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_PNEUMONIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | 0.449% |
| 5 | 1.397% | 2.612% |
| 10 | 3.45% | 5.796% |
| 15 | 6.716% | 10.749% |
| 20 | 11.246% | 17.778% |
Relationships between endpoints
↥Index endpoint: ASTHMA_PNEUMONIA – Asthma-related pneumonia
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data