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Asthma-related pneumonia or sepsis

ASTHMA_PNEUMONIA_AND_SEPSIS

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • J10_ASTHMA
54128

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

15365

6. Filter based on genotype QC (FinnGen only)

14798

Control definitions (FinnGen only)

Control exclude ASTHMA_HOSPITAL_PNEUMONIA
Control conditions not J10_ASTHMA

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 14798 7686 7112
Unadjusted period prevalence (%) 3.28 3.02 3.57
Median age at first event (years) 60.55 56.24 65.19

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ASTHMA_PNEUMONIA_AND_SEPSIS – Asthma-related pneumonia or sepsis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).