asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
54128 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
28283 |
6. Filter based on genotype QC (FinnGen only) |
27242 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_HOSPITAL_INFECTIONS
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma-related infections
based on the number of shared cases.
Similar with more cases:
- Asthma, hospital admission 2, infections
- Asthma
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 296918 | 145717 | 149348 |
| Only index persons | 246457 | 124868 | 121589 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.16 | 4.17 | 4.17 |
| Only index persons | 4.62 | 4.59 | 4.64 |
| Median age at first event (years) | |||
| Whole population | 34.23 | 48.46 | 19.95 |
| Only index persons | 33.15 | 46.08 | 19.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 27242 | 15537 | 11705 |
| Unadjusted period prevalence (%) | 6.01 | 6.10 | 5.88 |
| Median age at first event (years) | 47.81 | 45.70 | 50.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_INFECTIONS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_INFECTIONS | 1.865 [1.7, 2.04] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.292 |
During the follow-up period (1.1.1998 — 31.12.2019), 22532 out of 102793 females with ASTHMA_INFECTIONS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_INFECTIONS | 2.056 [1.85, 2.28] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 19126 out of 92956 males with ASTHMA_INFECTIONS died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_INFECTIONS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.135% | 0.311% |
| 5 | 1.026% | 1.899% |
| 10 | 2.819% | 4.685% |
| 15 | 5.045% | 8.553% |
| 20 | 8.848% | 14.214% |
Relationships between endpoints
↥Index endpoint: ASTHMA_INFECTIONS – Asthma-related infections
GWS hits: 26
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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