bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]
Asthma-related acute respiratory infections
DOID EFO Endpoint Browser PheWeb
ASTHMA_ACUTE_RESPIRATORY_INFECTIONS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
54128 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
20759 |
6. Filter based on genotype QC (FinnGen only) |
19980 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_INFECTIONS
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma-related acute respiratory infections
based on the number of shared cases.
Similar with more cases:
- Asthma-related infections
- Asthma, hospital admission 2, infections
- Asthma
- Asthma
- Asthma, including avohilmo
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 224004 | 108164 | 114843 |
| Only index persons | 188554 | 93497 | 95057 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.15 | 3.10 | 3.21 |
| Only index persons | 3.53 | 3.44 | 3.63 |
| Median age at first event (years) | |||
| Whole population | 25.95 | 37.95 | 14.32 |
| Only index persons | 27.72 | 37.58 | 18.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19980 | 11920 | 8060 |
| Unadjusted period prevalence (%) | 4.43 | 4.68 | 4.05 |
| Median age at first event (years) | 36.62 | 42.16 | 28.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_ACUTE_RESPIRATORY_INFECTIONS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_ACUTE_RESPIRATORY_INFECTIONS | 1.673 [1.53, 1.83] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.395 |
During the follow-up period (1.1.1998 — 31.12.2019), 13783 out of 79741 females with ASTHMA_ACUTE_RESPIRATORY_INFECTIONS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_ACUTE_RESPIRATORY_INFECTIONS | 1.798 [1.61, 2.01] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 10514 out of 73640 males with ASTHMA_ACUTE_RESPIRATORY_INFECTIONS died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_ACUTE_RESPIRATORY_INFECTIONS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.359% |
| 5 | 0.998% | 2.268% |
| 10 | 2.509% | 5.268% |
| 15 | 4.738% | 9.886% |
| 20 | 8.147% | 16.639% |
Relationships between endpoints
↥Index endpoint: ASTHMA_ACUTE_RESPIRATORY_INFECTIONS – Asthma-related acute respiratory infections
GWS hits: 17
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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