recurrent pneumonia: recurrent pneumonia due to nontuberculous mycobacterium infections
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
347 |
4. Check minimum number of eventsNone |
347 |
5. Include endpointsNone |
347 |
6. Filter based on genotype QC (FinnGen only) |
334 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_PNEUMONIA
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
A31
Name in latin
Infectio pulmonalis mycobacterialis
Similar endpoints
↥List of similar endpoints to
Atypical mycobacterium lung infection
based on the number of shared cases.
Similar with more cases:
- Pneumonias (Asthma/COPD co-morbidities)
- COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia
- COPD/asthma related pneumonia or pneumonia derived septicaemia
- COPD/asthma/ILD related infections
- COPD/asthma related infections
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3018 | 1576 | 1387 |
| Only index persons | 2203 | 1277 | 926 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.38 | 71.46 | 64.83 |
| Only index persons | 67.81 | 70.61 | 63.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 334 | 189 | 145 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | 67.70 | 66.57 | 69.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint MYCOBLUNGATYPICA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MYCOBLUNGATYPICA | 1.744 [1.51, 2.02] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.209 |
During the follow-up period (1.1.1998 — 31.12.2019), 571 out of 1246 females with MYCOBLUNGATYPICA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MYCOBLUNGATYPICA | 3.148 [2.47, 4.01] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 490 out of 842 males with MYCOBLUNGATYPICA died.
Mortality risk
Mortality risk for people of age
years, who have MYCOBLUNGATYPICA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.602% |
| 5 | 0.936% | 3.554% |
| 10 | 2.477% | 8.216% |
| 15 | 5.023% | 15.414% |
| 20 | 8.501% | 25.509% |
Relationships between endpoints
↥Index endpoint: MYCOBLUNGATYPICA – Atypical mycobacterium lung infection
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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