Atypical mycobacterium lung infection

MYCOBLUNGATYPICA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A31.0
  • Hospital discharge: ICD-9 310
  • Cause of death: ICD-10 A31.0
  • Cause of death: ICD-9 310

2 out of 7 registries used, show all original rules.

347

4. Check minimum number of events

None

347

5. Include endpoints

None

347

6. Filter based on genotype QC (FinnGen only)

334

Control definitions (FinnGen only)

Control exclude ASTHMA_PNEUMONIA

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 A31
Name in latin Infectio pulmonalis mycobacterialis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3018 1576 1387
Only index persons 2203 1277 926
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 68.38 71.46 64.83
Only index persons 67.81 70.61 63.93

-FinnGen-

Key figures

All Female Male
Number of individuals 334 189 145
Unadjusted period prevalence (%) 0.07 0.07 0.07
Median age at first event (years) 67.70 66.57 69.18

-FinRegistry-

Age distribution of first events

01020304050607080900100200300400500600700800AgeIndividuals

-FinnGen-

Age distribution of first events

0203040506070800102030405060708090100AgeIndividuals

-FinRegistry-

Year distribution of first events

19751980198519901995200020052010201520202022050100150200250300350400450500YearIndividuals

-FinnGen-

Year distribution of first events

19701975198019851990199520002005201020152020202301020304050607080YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint MYCOBLUNGATYPICA and mortality.

Females

Parameter HR [95% CI] p-value
MYCOBLUNGATYPICA 1.744 [1.51, 2.02] < 0.001
Birth year 0.995 [0.99, 1.0] 0.209

During the follow-up period (1.1.1998 — 31.12.2019), 571 out of 1246 females with MYCOBLUNGATYPICA died.

Males

Parameter HR [95% CI] p-value
MYCOBLUNGATYPICA 3.148 [2.47, 4.01] < 0.001
Birth year 0.986 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 490 out of 842 males with MYCOBLUNGATYPICA died.

Mortality risk

Mortality risk for people of age

years, who have MYCOBLUNGATYPICA.

N-year risk Females Males
1 0.123% 0.602%
5 0.936% 3.554%
10 2.477% 8.216%
15 5.023% 15.414%
20 8.501% 25.509%

Relationships between endpoints

Index endpoint: MYCOBLUNGATYPICA – Atypical mycobacterium lung infection

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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