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Childhood asthma (age<16)

Endpoint Browser PheWeb

ASTHMA_CHILD_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: EVENT_AGE<16

Registry filters:

  • Hospital discharge: ICD-10 — J45, J46
  • Hospital discharge: ICD-9 — 493
  • Hospital discharge: ICD-8 — 493
  • Cause of death: ICD-10 — J45, J46
  • Cause of death: ICD-9 — 493
  • Cause of death: ICD-8 — 493

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 173424 66892 106463
Only index persons 146118 57018 89100
Unadjusted period prevalence (%)
Whole population 2.57 1.92 2.97
Only index persons 2.89 2.10 3.40
Median age at first event (years)
Whole population 4.94 5.63 4.51
Only index persons 5.54 6.34 5.02

-FinnGen-

Key figures

All Female Male
Number of individuals 7537 4375 3162
Unadjusted period prevalence (%) 1.66 1.72 1.59
Median age at first event (years) 7.06 7.82 6.01

-FinRegistry-

Age distribution of first events

01020304050607080900k10k20k30k40k50k60k70k80k90k100k110k120k130kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5k5.0kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k2k4k6k8k10k12k14k16k18k20k22k24k26k28k30kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000123456789101112AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

010203040506070809010002468101214161820AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint ASTHMA_CHILD_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
ASTHMA_CHILD_EXMORE 1.899 [1.57, 2.29] < 0.001
Birth year 0.995 [0.99, 1.0] 0.204

During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 49175 females with ASTHMA_CHILD_EXMORE died.

Males

Parameter HR [95% CI] p-value
ASTHMA_CHILD_EXMORE 1.072 [0.94, 1.22] 0.296
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 76127 males with ASTHMA_CHILD_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have ASTHMA_CHILD_EXMORE.

N-year risk Females Males
1 0.183% 0.168%
5 0.889% 1.242%
10 2.566% 2.972%
15 5.292% 5.625%
20 9.335% 9.347%

Relationships between endpoints

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Index endpoint: ASTHMA_CHILD_EXMORE – Childhood asthma (age<16)

GWS hits: 24

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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