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Intestinal infectious diseases

DOID EFO Endpoint Browser PheWeb

AB1_INTESTINAL_INFECTIONS

amebiasis: A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A00-A09
  • Hospital discharge: ICD-9 — 00[1-9]
  • Hospital discharge: ICD-8 — 00[0-9]
  • Cause of death: ICD-10 — A00-A09
  • Cause of death: ICD-9 — 00[1-9]
  • Cause of death: ICD-8 — 00[0-9]

2 out of 7 registries used, show all original rules.

52392

4. Check minimum number of events

None

52392

5. Include endpoints

52392

6. Filter based on genotype QC (FinnGen only)

50302

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 671437 331887 335586
Only index persons 563226 278229 284997
Unadjusted period prevalence (%)
Whole population 9.41 9.51 9.38
Only index persons 10.56 10.23 10.88
Median age at first event (years)
Whole population 28.35 36.22 20.19
Only index persons 26.77 33.55 20.14

-FinnGen-

Key figures

All Female Male
Number of individuals 50302 27485 22817
Unadjusted period prevalence (%) 11.10 10.79 11.46
Median age at first event (years) 37.53 36.56 38.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_INTESTINAL_INFECTIONS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_INTESTINAL_INFECTIONS 1.841 [1.69, 2.01] < 0.001
Birth year 0.994 [0.99, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 55934 out of 221436 females with AB1_INTESTINAL_INFECTIONS died.

Males

Parameter HR [95% CI] p-value
AB1_INTESTINAL_INFECTIONS 2.188 [1.97, 2.43] < 0.001
Birth year 0.988 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 38770 out of 194416 males with AB1_INTESTINAL_INFECTIONS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_INTESTINAL_INFECTIONS.

N-year risk Females Males
1 0.18% 0.362%
5 1.158% 2.335%
10 2.505% 6.121%
15 4.545% 11.059%
20 8.01% 17.87%

Relationships between endpoints

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Index endpoint: AB1_INTESTINAL_INFECTIONS – Intestinal infectious diseases

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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