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Diarrhoea and gastroenteritis of presumed infectious origin

EFO Endpoint Browser PheWeb

AB1_GASTROENTERITIS_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A09
  • Hospital discharge: ICD-9 — 009.
  • Hospital discharge: ICD-8 — 00[9]
  • Cause of death: ICD-10 — A09
  • Cause of death: ICD-9 — 009.
  • Cause of death: ICD-8 — 00[9]

2 out of 7 registries used, show all original rules.

37436

4. Check minimum number of events

None

37436

5. Include endpoints

None

37436

6. Filter based on genotype QC (FinnGen only)

35960

Control definitions (FinnGen only)

Control exclude AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 453638 225856 225054
Only index persons 374205 186263 187942
Unadjusted period prevalence (%)
Whole population 6.36 6.47 6.29
Only index persons 7.01 6.85 7.17
Median age at first event (years)
Whole population 32.91 44.68 20.76
Only index persons 31.40 42.06 20.83

-FinnGen-

Key figures

All Female Male
Number of individuals 35960 19346 16614
Unadjusted period prevalence (%) 7.94 7.60 8.34
Median age at first event (years) 40.21 40.71 39.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_GASTROENTERITIS_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_GASTROENTERITIS_NOS 1.704 [1.56, 1.86] < 0.001
Birth year 0.994 [0.99, 1.0] 0.141

During the follow-up period (1.1.1998 — 31.12.2019), 43891 out of 162768 females with AB1_GASTROENTERITIS_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_GASTROENTERITIS_NOS 1.964 [1.76, 2.19] < 0.001
Birth year 0.989 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 28896 out of 132443 males with AB1_GASTROENTERITIS_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_GASTROENTERITIS_NOS.

N-year risk Females Males
1 0.137% 0.36%
5 0.867% 2.149%
10 2.286% 5.633%
15 4.458% 10.099%
20 7.838% 17.276%

Relationships between endpoints

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Index endpoint: AB1_GASTROENTERITIS_NOS – Diarrhoea and gastroenteritis of presumed infectious origin

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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