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Amoebiasis

EFO Endpoint Browser PheWeb

AB1_AMOEBIASIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A06
  • Hospital discharge: ICD-9 — 006.
  • Hospital discharge: ICD-8 — 00[6]
  • Cause of death: ICD-10 — A06
  • Cause of death: ICD-9 — 006.
  • Cause of death: ICD-8 — 00[6]

2 out of 7 registries used, show all original rules.

193

4. Check minimum number of events

None

193

5. Include endpoints

None

193

6. Filter based on genotype QC (FinnGen only)

182

Control definitions (FinnGen only)

Control exclude AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2264 1163 1084
Only index persons 1862 978 884
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 35.75 39.01 31.87
Only index persons 35.28 37.77 32.54

-FinnGen-

Key figures

All Female Male
Number of individuals 182 108 74
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 44.91 45.09 44.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_AMOEBIASIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_AMOEBIASIS 1.655 [1.34, 2.04] < 0.001
Birth year 0.995 [0.99, 1.0] 0.218

During the follow-up period (1.1.1998 — 31.12.2019), 241 out of 965 females with AB1_AMOEBIASIS died.

Males

Parameter HR [95% CI] p-value
AB1_AMOEBIASIS 1.981 [1.42, 2.76] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 202 out of 870 males with AB1_AMOEBIASIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_AMOEBIASIS.

N-year risk Females Males
1 0.174% 0.37%
5 0.862% 2.264%
10 2.187% 5.55%
15 4.515% 10.558%
20 7.752% 17.621%

Relationships between endpoints

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Index endpoint: AB1_AMOEBIASIS – Amoebiasis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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