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Other salmonella infections

EFO Endpoint Browser PheWeb

AB1_SALMONELLA_OTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A02
  • Hospital discharge: ICD-9 — 003.
  • Hospital discharge: ICD-8 — 00[3]
  • Cause of death: ICD-10 — A02
  • Cause of death: ICD-9 — 003.
  • Cause of death: ICD-8 — 00[3]

2 out of 7 registries used, show all original rules.

1310

4. Check minimum number of events

None

1310

5. Include endpoints

None

1310

6. Filter based on genotype QC (FinnGen only)

1265

Control definitions (FinnGen only)

Control exclude AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12276 5907 6253
Only index persons 10203 5051 5152
Unadjusted period prevalence (%)
Whole population 0.17 0.17 0.17
Only index persons 0.19 0.19 0.20
Median age at first event (years)
Whole population 35.51 36.62 34.14
Only index persons 32.12 33.79 30.49

-FinnGen-

Key figures

All Female Male
Number of individuals 1265 713 552
Unadjusted period prevalence (%) 0.28 0.28 0.28
Median age at first event (years) 37.46 33.74 42.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_SALMONELLA_OTH and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SALMONELLA_OTH 1.149 [0.96, 1.38] 0.131
Birth year 0.997 [0.99, 1.01] 0.478

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 2075 females with AB1_SALMONELLA_OTH died.

Males

Parameter HR [95% CI] p-value
AB1_SALMONELLA_OTH 1.191 [1.02, 1.39] 0.03
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 285 out of 2249 males with AB1_SALMONELLA_OTH died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SALMONELLA_OTH.

N-year risk Females Males
1 0.12% 0.248%
5 0.725% 1.439%
10 1.841% 3.618%
15 3.433% 7.083%
20 6.244% 11.805%

Relationships between endpoints

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Index endpoint: AB1_SALMONELLA_OTH – Other salmonella infections

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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