Viral and other specified intestinal infections

AB1_VIRAL_OTHER_INTEST_INFECTIONS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A08
  • Hospital discharge: ICD-9 008.
  • Hospital discharge: ICD-8 008[8-9]
  • Cause of death: ICD-10 A08
  • Cause of death: ICD-9 008.
  • Cause of death: ICD-8 008[8-9]

2 out of 7 registries used, show all original rules.

10188

4. Check minimum number of events

None

10188

5. Include endpoints

None

10188

6. Filter based on genotype QC (FinnGen only)

9801

Control definitions (FinnGen only)

Control exclude AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 185652 84909 100119
Only index persons 162169 72764 89405
Unadjusted period prevalence (%)
Whole population 2.62 2.43 2.80
Only index persons 3.08 2.67 3.41
Median age at first event (years)
Whole population 4.21 3.98 4.02
Only index persons 3.67 3.44 3.85

-FinnGen-

Key figures

All Female Male
Number of individuals 9801 5428 4373
Unadjusted period prevalence (%) 2.16 2.13 2.20
Median age at first event (years) 13.89 9.07 19.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAL_OTHER_INTEST_INFECTIONS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_OTHER_INTEST_INFECTIONS 1.696 [1.53, 1.88] < 0.001
Birth year 0.992 [0.98, 1.0] 0.052

During the follow-up period (1.1.1998 — 31.12.2019), 8564 out of 55610 females with AB1_VIRAL_OTHER_INTEST_INFECTIONS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_OTHER_INTEST_INFECTIONS 1.826 [1.6, 2.09] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 5180 out of 60989 males with AB1_VIRAL_OTHER_INTEST_INFECTIONS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_OTHER_INTEST_INFECTIONS.

N-year risk Females Males
1 0.124% 0.364%
5 0.785% 1.993%
10 2.162% 4.864%
15 4.168% 8.57%
20 7.073% 14.865%

Relationships between endpoints

Index endpoint: AB1_VIRAL_OTHER_INTEST_INFECTIONS – Viral and other specified intestinal infections

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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