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Enterocolitis due to Clostridium difficile

DOID EFO Endpoint Browser PheWeb

C_DIFFICILE_ENTEROCOLITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A04.7
  • Hospital discharge: ICD-9 — 0084F
  • Cause of death: ICD-10 — A04.7
  • Cause of death: ICD-9 — 0084F

2 out of 7 registries used, show all original rules.

3907

4. Check minimum number of events

None

3907

5. Include endpoints

None

3907

6. Filter based on genotype QC (FinnGen only)

3760

Control definitions (FinnGen only)

Control exclude IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 A04
Name in latin Enterocolitis a Clostridio difficili

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 41118 23834 16897
Only index persons 33270 19785 13485
Unadjusted period prevalence (%)
Whole population 0.59 0.68 0.47
Only index persons 0.64 0.73 0.51
Median age at first event (years)
Whole population 74.22 75.95 71.78
Only index persons 73.29 75.05 70.72

-FinnGen-

Key figures

All Female Male
Number of individuals 3760 1933 1827
Unadjusted period prevalence (%) 0.84 0.76 0.92
Median age at first event (years) 67.05 62.90 71.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C_DIFFICILE_ENTEROCOLITIS and mortality.

Females

Parameter HR [95% CI] p-value
C_DIFFICILE_ENTEROCOLITIS 2.63 [2.35, 2.94] < 0.001
Birth year 0.998 [0.99, 1.01] 0.581

During the follow-up period (1.1.1998 — 31.12.2019), 10356 out of 18298 females with C_DIFFICILE_ENTEROCOLITIS died.

Males

Parameter HR [95% CI] p-value
C_DIFFICILE_ENTEROCOLITIS 3.406 [2.93, 3.96] < 0.001
Birth year 0.989 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 7585 out of 12742 males with C_DIFFICILE_ENTEROCOLITIS died.

Mortality risk

Mortality risk for people of age

years, who have C_DIFFICILE_ENTEROCOLITIS.

N-year risk Females Males
1 0.233% 0.607%
5 1.604% 3.666%
10 4.341% 9.632%
15 7.947% 18.176%
20 13.42% 29.45%

Relationships between endpoints

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Index endpoint: C_DIFFICILE_ENTEROCOLITIS – Enterocolitis due to Clostridium difficile

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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