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Other bacterial intestinal infections

EFO Endpoint Browser PheWeb

AB1_BACT_INTEST_OTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A04, A05
  • Hospital discharge: ICD-9 — 00[5]
  • Hospital discharge: ICD-8 — 00[5]|008[0-3]
  • Cause of death: ICD-10 — A04, A05
  • Cause of death: ICD-9 — 00[5]
  • Cause of death: ICD-8 — 00[5]|008[0-3]

2 out of 7 registries used, show all original rules.

7191

4. Check minimum number of events

None

7191

5. Include endpoints

None

7191

6. Filter based on genotype QC (FinnGen only)

6837

Control definitions (FinnGen only)

Control exclude AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 68007 37325 30086
Only index persons 58839 32832 26007
Unadjusted period prevalence (%)
Whole population 0.96 1.07 0.84
Only index persons 1.11 1.21 0.99
Median age at first event (years)
Whole population 66.74 69.07 63.82
Only index persons 64.84 67.03 62.07

-FinnGen-

Key figures

All Female Male
Number of individuals 6837 3626 3211
Unadjusted period prevalence (%) 1.51 1.42 1.61
Median age at first event (years) 62.08 57.82 66.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_BACT_INTEST_OTH and mortality.

Females

Parameter HR [95% CI] p-value
AB1_BACT_INTEST_OTH 2.526 [2.26, 2.82] < 0.001
Birth year 0.991 [0.98, 1.0] 0.04

During the follow-up period (1.1.1998 — 31.12.2019), 12694 out of 30715 females with AB1_BACT_INTEST_OTH died.

Males

Parameter HR [95% CI] p-value
AB1_BACT_INTEST_OTH 2.604 [2.3, 2.95] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 9789 out of 24105 males with AB1_BACT_INTEST_OTH died.

Mortality risk

Mortality risk for people of age

years, who have AB1_BACT_INTEST_OTH.

N-year risk Females Males
1 0.204% 0.598%
5 1.142% 3.254%
10 2.953% 7.317%
15 5.527% 14.273%
20 10.265% 22.754%

Relationships between endpoints

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Index endpoint: AB1_BACT_INTEST_OTH – Other bacterial intestinal infections

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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