dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
90 |
4. Check minimum number of eventsNone |
90 |
5. Include endpointsNone |
90 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
Control exclude
IBD_BACT_INTEST_INFECTIONS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
A04
Name in latin
Infectio ab Escherichia coli enteropathogenica
Similar endpoints
↥List of similar endpoints to
Enteropathogenic Escherichia coli infection
based on the number of shared cases.
Similar with more cases:
- Bacterial intestinal infections, IBD co-morbidities
- Other bacterial intestinal infections
- Infections, IBD-co-morbidities
- Intestinal infectious diseases
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 847 | 440 | 403 |
| Only index persons | 730 | 388 | 342 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 59.41 | 61.54 | 56.93 |
| Only index persons | 58.07 | 59.97 | 55.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 40 | 44 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 63.17 | 62.78 | 63.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ENTEROPATH_E_COLI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ENTEROPATH_E_COLI | 2.339 [1.61, 3.41] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.938 |
During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 367 females with ENTEROPATH_E_COLI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ENTEROPATH_E_COLI | 2.601 [1.56, 4.34] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 334 males with ENTEROPATH_E_COLI died.
Mortality risk
Mortality risk for people of age
years, who have ENTEROPATH_E_COLI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.256% | 0.401% |
| 5 | 1.533% | 2.463% |
| 10 | 3.763% | 6.297% |
| 15 | 7.396% | 12.017% |
| 20 | 12.958% | 19.635% |
Relationships between endpoints
↥Index endpoint: ENTEROPATH_E_COLI – Enteropathogenic Escherichia coli infection
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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