No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
59226 |
6. Filter based on genotype QC (FinnGen only) |
57251 |
Control definitions (FinnGen only)
Control exclude
F5_BEHAVE
Extra metadata
First used in FinnGen datafreeze
DF2
Sleep disorders (combined)
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 373804 | 138015 | 234135 |
| Only index persons | 355186 | 133240 | 221946 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.56 | 3.95 | 6.54 |
| Only index persons | 7.13 | 4.90 | 8.47 |
| Median age at first event (years) | |||
| Whole population | 53.04 | 54.84 | 51.99 |
| Only index persons | 53.04 | 54.93 | 51.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57251 | 25054 | 32197 |
| Unadjusted period prevalence (%) | 13.40 | 9.84 | 16.17 |
| Median age at first event (years) | 55.43 | 55.39 | 55.46 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SLEEP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLEEP | 1.371 [1.23, 1.53] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 7503 out of 98576 females with SLEEP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLEEP | 1.298 [1.18, 1.42] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 18538 out of 170389 males with SLEEP died.
Mortality risk
Mortality risk for people of age
years, who have SLEEP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.276% |
| 5 | 0.802% | 1.401% |
| 10 | 1.71% | 3.613% |
| 15 | 3.176% | 6.971% |
| 20 | 5.831% | 12.18% |
Relationships between endpoints
↥Index endpoint: SLEEP – Sleep disorders (combined)
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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