No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
6044 |
4. Check minimum number of eventsNone |
6044 |
5. Include endpointsNone |
6044 |
6. Filter based on genotype QC (FinnGen only) |
5763 |
Control definitions (FinnGen only)
Control exclude
F5_SLEEP
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Insomnia
based on the number of shared cases.
Similar with more cases:
- Sleep disorders
- Behavioural syndromes associated with physiological disturbances and physical factors
- Sleep disorders (combined)
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 47561 | 25957 | 21322 |
| Only index persons | 45332 | 25198 | 20134 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.67 | 0.74 | 0.60 |
| Only index persons | 0.86 | 0.93 | 0.77 |
| Median age at first event (years) | |||
| Whole population | 45.75 | 46.60 | 44.81 |
| Only index persons | 45.53 | 46.40 | 44.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5763 | 3673 | 2090 |
| Unadjusted period prevalence (%) | 1.30 | 1.44 | 1.05 |
| Median age at first event (years) | 49.74 | 48.15 | 52.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_INSOMNIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_INSOMNIA | 1.584 [1.38, 1.82] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.141 |
During the follow-up period (1.1.1998 — 31.12.2019), 1815 out of 17928 females with F5_INSOMNIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_INSOMNIA | 2.16 [1.89, 2.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 2637 out of 16039 males with F5_INSOMNIA died.
Mortality risk
Mortality risk for people of age
years, who have F5_INSOMNIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.458% |
| 5 | 0.795% | 2.887% |
| 10 | 2.327% | 6.982% |
| 15 | 4.446% | 13.114% |
| 20 | 7.884% | 21.564% |
Relationships between endpoints
↥Index endpoint: F5_INSOMNIA – Insomnia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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