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Other sleep disorders

DOID EFO Endpoint Browser PheWeb

G6_SLEEPDISOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G47
  • Hospital discharge: ICD-9 — 3478|3074
  • Hospital discharge: excluded ICD-10 — G47.3, G47.4
  • Cause of death: ICD-10 — G47
  • Cause of death: ICD-9 — 3478|3074
  • Cause of death: excluded ICD-10 — G47.3, G47.4

2 out of 7 registries used, show all original rules.

4248

4. Check minimum number of events

None

4248

5. Include endpoints

None

4248

6. Filter based on genotype QC (FinnGen only)

4080

Control definitions (FinnGen only)

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47
Name in latin Perturbationes somni (organicae)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37822 14792 22784
Only index persons 33930 13696 20234
Unadjusted period prevalence (%)
Whole population 0.55 0.42 0.64
Only index persons 0.66 0.50 0.77
Median age at first event (years)
Whole population 48.61 48.62 48.49
Only index persons 47.84 48.07 47.68

-FinnGen-

Key figures

All Female Male
Number of individuals 4080 1930 2150
Unadjusted period prevalence (%) 0.93 0.76 1.08
Median age at first event (years) 49.53 47.48 51.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_SLEEPDISOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_SLEEPDISOTH 1.334 [1.19, 1.49] < 0.001
Birth year 0.997 [0.99, 1.01] 0.532

During the follow-up period (1.1.1998 — 31.12.2019), 1071 out of 9820 females with G6_SLEEPDISOTH died.

Males

Parameter HR [95% CI] p-value
G6_SLEEPDISOTH 1.354 [1.24, 1.48] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2424 out of 14274 males with G6_SLEEPDISOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_SLEEPDISOTH.

N-year risk Females Males
1 0.118% 0.226%
5 0.882% 1.469%
10 2.276% 3.58%
15 4.204% 6.951%
20 7.155% 11.548%

Relationships between endpoints

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Index endpoint: G6_SLEEPDISOTH – Other sleep disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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