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Nonorganic sleeping disorders

Endpoint Browser PheWeb

KRA_PSY_SLEEP_NONORG_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F51
  • Hospital discharge: ICD-9 — 3074
  • Hospital discharge: ICD-8 — 30640
  • Cause of death: ICD-10 — F51
  • Cause of death: ICD-9 — 3074
  • Cause of death: ICD-8 — 30640

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F50-F59
Name in latin Perturbationes somni non organicae

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 66627 34456 31779
Only index persons 60557 32275 28282
Unadjusted period prevalence (%)
Whole population 0.94 0.99 0.89
Only index persons 1.14 1.19 1.08
Median age at first event (years)
Whole population 40.02 41.74 38.15
Only index persons 40.66 42.32 38.76

-FinnGen-

Key figures

All Female Male
Number of individuals 7139 4478 2661
Unadjusted period prevalence (%) 1.60 1.76 1.34
Median age at first event (years) 47.32 45.48 50.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_SLEEP_NONORG_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_SLEEP_NONORG_EXMORE 1.704 [1.46, 1.99] < 0.001
Birth year 0.994 [0.99, 1.0] 0.131

During the follow-up period (1.1.1998 — 31.12.2019), 1880 out of 22518 females with KRA_PSY_SLEEP_NONORG_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_SLEEP_NONORG_EXMORE 2.505 [2.15, 2.92] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2592 out of 20948 males with KRA_PSY_SLEEP_NONORG_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_SLEEP_NONORG_EXMORE.

N-year risk Females Males
1 0.11% 0.406%
5 0.878% 2.418%
10 2.091% 6.362%
15 3.916% 11.786%
20 7.157% 19.29%

Relationships between endpoints

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Index endpoint: KRA_PSY_SLEEP_NONORG_EXMORE – Nonorganic sleeping disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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