No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1134 |
4. Check minimum number of eventsNone |
1134 |
5. Include endpointsNone |
1134 |
6. Filter based on genotype QC (FinnGen only) |
1081 |
Control definitions (FinnGen only)
Control exclude
F5_SLEEP
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Sleep disorders, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Nonorganic sleeping disorders
- Nonorganic sleeping disorders
- Sleep disorders
- Behavioural syndromes associated with physiological disturbances and physical factors
- Sleep disorders (combined)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11736 | 5917 | 5770 |
| Only index persons | 10393 | 5350 | 5043 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.17 | 0.16 |
| Only index persons | 0.19 | 0.20 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 26.58 | 31.11 | 21.85 |
| Only index persons | 29.83 | 33.99 | 25.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1081 | 718 | 363 |
| Unadjusted period prevalence (%) | 0.25 | 0.28 | 0.18 |
| Median age at first event (years) | 43.28 | 41.72 | 46.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_SLEEP_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SLEEP_NOS | 1.915 [1.54, 2.39] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 4213 females with F5_SLEEP_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SLEEP_NOS | 2.307 [1.88, 2.83] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 4613 males with F5_SLEEP_NOS died.
Mortality risk
Mortality risk for people of age
years, who have F5_SLEEP_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.436% |
| 5 | 1.021% | 2.599% |
| 10 | 2.371% | 6.311% |
| 15 | 4.257% | 11.178% |
| 20 | 7.481% | 18.768% |
Relationships between endpoints
↥Index endpoint: F5_SLEEP_NOS – Sleep disorders, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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