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Sleep apnoea

DOID EFO Endpoint Browser PheWeb

G6_SLEEPAPNO

sleep apnea: A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G47.3
  • Hospital discharge: ICD-9 — 3472
  • Cause of death: ICD-10 — G47.3
  • Cause of death: ICD-9 — 3472

2 out of 7 registries used, show all original rules.

51816

4. Check minimum number of events

None

51816

5. Include endpoints

None

51816

6. Filter based on genotype QC (FinnGen only)

50200

Control definitions (FinnGen only)

Control exclude G6_NARCOCATA, G6_SLEEPDISOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G47
Name in latin Apnoea intrasomnalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 299915 99073 199632
Only index persons 288611 96978 191633
Unadjusted period prevalence (%)
Whole population 4.66 2.84 5.58
Only index persons 6.06 3.57 7.32
Median age at first event (years)
Whole population 54.62 57.21 53.35
Only index persons 54.55 57.21 53.21

-FinnGen-

Key figures

All Female Male
Number of individuals 50200 20411 29789
Unadjusted period prevalence (%) 12.14 8.02 14.96
Median age at first event (years) 56.34 56.86 55.98

-FinRegistry-

Age distribution of first events

01020304050607080900k10k20k30k40k50k60k70k80k90kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900k2k4k6k8k10k12k14k16kAgeIndividuals

-FinRegistry-

Year distribution of first events

19701975199019952000200520102015202020220k10k20k30k40k50k60k70k80k90kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230k2k4k6k8k10k12k14k16kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

0102030405060708090100024681012141618AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

010203040506070809010005101520253035AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint G6_SLEEPAPNO and mortality.

Females

Parameter HR [95% CI] p-value
G6_SLEEPAPNO 1.299 [1.17, 1.45] < 0.001
Birth year 0.997 [0.99, 1.0] 0.467

During the follow-up period (1.1.1998 — 31.12.2019), 5162 out of 72202 females with G6_SLEEPAPNO died.

Males

Parameter HR [95% CI] p-value
G6_SLEEPAPNO 1.153 [1.05, 1.27] 0.003
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 15538 out of 147116 males with G6_SLEEPAPNO died.

Mortality risk

Mortality risk for people of age

years, who have G6_SLEEPAPNO.

N-year risk Females Males
1 0.102% 0.183%
5 0.653% 1.187%
10 1.977% 2.987%
15 3.707% 5.684%
20 6.428% 9.619%

Relationships between endpoints

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Index endpoint: G6_SLEEPAPNO – Sleep apnoea

GWS hits: 28

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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