sleep apnea: A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
51816 |
4. Check minimum number of eventsNone |
51816 |
5. Include endpointsNone |
51816 |
6. Filter based on genotype QC (FinnGen only) |
50200 |
Control definitions (FinnGen only)
Control exclude
G6_NARCOCATA, G6_SLEEPDISOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G47
Name in latin
Apnoea intrasomnalis
Similar endpoints
↥List of similar endpoints to
Sleep apnoea
based on the number of shared cases.
Similar with more cases:
- Sleep apnoea, including avohilmo
- Sleep disorders (combined)
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 299915 | 99073 | 199632 |
| Only index persons | 288611 | 96978 | 191633 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.66 | 2.84 | 5.58 |
| Only index persons | 6.06 | 3.57 | 7.32 |
| Median age at first event (years) | |||
| Whole population | 54.62 | 57.21 | 53.35 |
| Only index persons | 54.55 | 57.21 | 53.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 50200 | 20411 | 29789 |
| Unadjusted period prevalence (%) | 12.14 | 8.02 | 14.96 |
| Median age at first event (years) | 56.34 | 56.86 | 55.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_SLEEPAPNO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_SLEEPAPNO | 1.299 [1.17, 1.45] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.467 |
During the follow-up period (1.1.1998 — 31.12.2019), 5162 out of 72202 females with G6_SLEEPAPNO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_SLEEPAPNO | 1.153 [1.05, 1.27] | 0.003 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 15538 out of 147116 males with G6_SLEEPAPNO died.
Mortality risk
Mortality risk for people of age
years, who have G6_SLEEPAPNO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.102% | 0.183% |
| 5 | 0.653% | 1.187% |
| 10 | 1.977% | 2.987% |
| 15 | 3.707% | 5.684% |
| 20 | 6.428% | 9.619% |
Relationships between endpoints
↥Index endpoint: G6_SLEEPAPNO – Sleep apnoea
GWS hits: 28
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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