narcolepsy with cataplexy: Narcolepsy with cataplexy is a sleep disorder characterized by excessive day-time sleepiness associated with uncontrollable sleep urges and cataplexy (loss of muscle tone often triggered by pleasant emotions).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
226 |
4. Check minimum number of eventsNone |
226 |
5. Include endpointsNone |
226 |
6. Filter based on genotype QC (FinnGen only) |
218 |
Control definitions (FinnGen only)
Control exclude
G6_EPIPAROX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G47
Name in latin
Narcolepsia
Similar endpoints
↥List of similar endpoints to
Narcolepsy and cataplexy
based on the number of shared cases.
Similar with more cases:
- Sleep disorders (combined)
- Episodal and paroxysmal disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1805 | 929 | 870 |
| Only index persons | 1664 | 880 | 784 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 32.44 | 28.45 | 36.61 |
| Only index persons | 30.04 | 27.56 | 32.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 218 | 124 | 94 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 37.14 | 31.01 | 45.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_NARCOCATA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NARCOCATA | 1.095 [0.82, 1.46] | 0.53 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 635 males with G6_NARCOCATA died.
Mortality risk
Mortality risk for people of age
years, who have G6_NARCOCATA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.215% |
| 5 | No data | 1.126% |
| 10 | No data | 2.798% |
| 15 | No data | 5.169% |
| 20 | No data | 9.036% |
Relationships between endpoints
↥Index endpoint: G6_NARCOCATA – Narcolepsy and cataplexy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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