Maternal care related to the fetus and amniotic cavity and possible delivery problems

O15_MATERN_CARE

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	473681
1. Apply sex-specific rule only females	265735
2. Check conditions None	265735
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O30-O48 Cause of death: ICD-10 — O30-O48 2 out of 7 registries used, show all original rules.	50016
4. Check minimum number of events None	50016
5. Include endpoints O15_MULTIP_GEST O15_MULTIP_GEST_COMPLIC O15_MAT_CARE_MALPRESENT O15_MATERN_CARE_DISPROP O15_MATERN_CARE_PELVIC_ABNORM O15_MATERN_CARE_FETAL_ABNORM O15_MATERN_CARE_OTHER O15_POLYHYDR O15_AMNIOT_OTHER O15_MEMBR_PREMAT_RUPT O15_PLAC_DISORD O15_PLAC_PRAEVIA O15_PLAC_PREMAT_SEPAR O15_ANTEPART_HAEM_NAS O15_FALSE_LAB O15_PREG_PROLONGED	56605
6. Filter based on genotype QC (FinnGen only)	54085

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF3

NAME	O15_MATERN_CARE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE	O15_MULTIP_GEST\|O15_MULTIP_GEST_COMPLIC\|O15_MAT_CARE_MALPRESENT\|O15_MATERN_CARE_DISPROP\|O15_MATERN_CARE_PELVIC_ABNORM\|O15_MATERN_CARE_FETAL_ABNORM\|O15_MATERN_CARE_OTHER\|O15_POLYHYDR\|O15_AMNIOT_OTHER\|O15_MEMBR_PREMAT_RUPT\|O15_PLAC_DISORD\|O15_PLAC_PRAEVIA\|O15_PLAC_PREMAT_SEPAR\|O15_ANTEPART_HAEM_NAS\|O15_FALSE_LAB\|O15_PREG_PROLONGED
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O[3-4]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O[3-4]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Maternal care related to the fetus and amniotic cavity and possible delivery problems based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	460079	460079	-
Only index persons	455423	455423	-
Unadjusted period prevalence (%)
Whole population	13.18	13.18	-
Only index persons	16.74	16.74	-
Median age at first event (years)
Whole population	-	29.79	-
Only index persons	-	29.77	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54085	54085	-
Unadjusted period prevalence (%)	21.24	21.24	-
Median age at first event (years)	30.31	30.31	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_MATERN_CARE and mortality.

Females

Parameter	HR [95% CI]	p-value
O15_MATERN_CARE	0.558 [0.5, 0.63]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.309

During the follow-up period (1.1.1998 — 31.12.2019), 2091 out of 357103 females with O15_MATERN_CARE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_MATERN_CARE.

N-year risk	Females	Males
1	0.07%	No data
5	0.325%	No data
10	0.812%	No data
15	1.619%	No data
20	2.86%	No data

Relationships between endpoints

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Index endpoint: O15_MATERN_CARE – Maternal care related to the fetus and amniotic cavity and possible delivery problems

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R11 + FR

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Maternal care related to the fetus and amniotic cavity and possible delivery problems

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Maternal care related to the fetus and amniotic cavity and possible delivery problems (O15_MATERN_CARE)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints