Maternal care for other known or suspected fetal problems

O15_MATERN_CARE_OTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O36
  • Cause of death: ICD-10 O36

2 out of 7 registries used, show all original rules.

13372

4. Check minimum number of events

None

13372

5. Include endpoints

None

13372

6. Filter based on genotype QC (FinnGen only)

12760

Control definitions (FinnGen only)

Control exclude O15_MATERN_CARE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O30-O48
Name in latin Cura matris propter alia problemata fetalia nota sive suspecta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 105247 105247 -
Only index persons 104573 104573 -
Unadjusted period prevalence (%)
Whole population 3.01 3.01 -
Only index persons 3.84 3.84 -
Median age at first event (years)
Whole population - 30.22 -
Only index persons - 30.20 -

-FinnGen-

Key figures

All Female Male
Number of individuals 12760 12760 -
Unadjusted period prevalence (%) 5.01 5.01 -
Median age at first event (years) 30.87 30.87 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_MATERN_CARE_OTHER and mortality.

Females

Parameter HR [95% CI] p-value
O15_MATERN_CARE_OTHER 0.722 [0.63, 0.82] < 0.001
Birth year 0.99 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 576 out of 92175 females with O15_MATERN_CARE_OTHER died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_MATERN_CARE_OTHER.

N-year risk Females Males
1 0.054% No data
5 0.418% No data
10 0.896% No data
15 1.756% No data
20 3.074% No data

Relationships between endpoints

Index endpoint: O15_MATERN_CARE_OTHER – Maternal care for other known or suspected fetal problems

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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