placenta praevia: Abnormal placentation in which the placenta implants in the lower segment of the uterus (the zone of dilation) and may cover part or all of the opening of the cervix. It is often associated with serious antepartum bleeding and premature labor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1652 |
4. Check minimum number of eventsNone |
1652 |
5. Include endpointsNone |
1652 |
6. Filter based on genotype QC (FinnGen only) |
1585 |
Control definitions (FinnGen only)
Control exclude
O15_MATERN_CARE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O30-O48
Name in latin
Placenta praevia
Similar endpoints
↥List of similar endpoints to
Placenta praevia
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13295 | 13295 | - |
| Only index persons | 13162 | 13162 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.38 | - |
| Only index persons | 0.48 | 0.48 | - |
| Median age at first event (years) | |||
| Whole population | - | 32.14 | - |
| Only index persons | - | 32.12 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1585 | 1585 | - |
| Unadjusted period prevalence (%) | 0.62 | 0.62 | - |
| Median age at first event (years) | 32.17 | 32.17 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_PLAC_PRAEVIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_PLAC_PRAEVIA | 0.484 [0.36, 0.65] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.247 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 10191 females with O15_PLAC_PRAEVIA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_PLAC_PRAEVIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.045% | No data |
| 5 | 0.269% | No data |
| 10 | 0.725% | No data |
| 15 | 1.438% | No data |
| 20 | 2.38% | No data |
Relationships between endpoints
↥Index endpoint: O15_PLAC_PRAEVIA – Placenta praevia
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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