No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9650 |
4. Check minimum number of eventsNone |
9650 |
5. Include endpointsNone |
9650 |
6. Filter based on genotype QC (FinnGen only) |
9236 |
Control definitions (FinnGen only)
Control exclude
O15_MATERN_CARE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O30-O48
Name in latin
Ruptura membranarum fetalium praematura
Similar endpoints
↥List of similar endpoints to
Premature rupture of membranes
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 74821 | 74821 | - |
| Only index persons | 74107 | 74107 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.14 | 2.14 | - |
| Only index persons | 2.72 | 2.72 | - |
| Median age at first event (years) | |||
| Whole population | - | 30.02 | - |
| Only index persons | - | 30.01 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9236 | 9236 | - |
| Unadjusted period prevalence (%) | 3.63 | 3.63 | - |
| Median age at first event (years) | 30.49 | 30.49 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_MEMBR_PREMAT_RUPT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_MEMBR_PREMAT_RUPT | 0.562 [0.47, 0.67] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.164 |
During the follow-up period (1.1.1998 — 31.12.2019), 264 out of 58310 females with O15_MEMBR_PREMAT_RUPT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_MEMBR_PREMAT_RUPT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.059% | No data |
| 5 | 0.306% | No data |
| 10 | 0.776% | No data |
| 15 | 1.459% | No data |
| 20 | 2.687% | No data |
Relationships between endpoints
↥Index endpoint: O15_MEMBR_PREMAT_RUPT – Premature rupture of membranes
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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