Prolonged pregnancy

O15_PREG_PROLONGED

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O48
  • Hospital discharge: ICD-9 645
  • Cause of death: ICD-10 O48
  • Cause of death: ICD-9 645

2 out of 7 registries used, show all original rules.

6311

4. Check minimum number of events

None

6311

5. Include endpoints

None

6311

6. Filter based on genotype QC (FinnGen only)

6062

Control definitions (FinnGen only)

Control exclude O15_MATERN_CARE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O30-O48
Name in latin Graviditas prolongata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 54492 54492 -
Only index persons 54044 54044 -
Unadjusted period prevalence (%)
Whole population 1.56 1.56 -
Only index persons 1.99 1.99 -
Median age at first event (years)
Whole population - 29.78 -
Only index persons - 29.77 -

-FinnGen-

Key figures

All Female Male
Number of individuals 6062 6062 -
Unadjusted period prevalence (%) 2.38 2.38 -
Median age at first event (years) 30.34 30.34 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_PREG_PROLONGED and mortality.

Females

Parameter HR [95% CI] p-value
O15_PREG_PROLONGED 0.474 [0.39, 0.58] < 0.001
Birth year 0.989 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 39479 females with O15_PREG_PROLONGED died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREG_PROLONGED.

N-year risk Females Males
1 0.042% No data
5 0.239% No data
10 0.633% No data
15 1.179% No data
20 2.117% No data

Relationships between endpoints

Index endpoint: O15_PREG_PROLONGED – Prolonged pregnancy

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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