Maternal care for known or suspected fetal abnormality and damage

O15_MATERN_CARE_FETAL_ABNORM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O35
  • Cause of death: ICD-10 O35

2 out of 7 registries used, show all original rules.

6598

4. Check minimum number of events

None

6598

5. Include endpoints

None

6598

6. Filter based on genotype QC (FinnGen only)

6237

Control definitions (FinnGen only)

Control exclude O15_MATERN_CARE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O30-O48
Name in latin Cura matris propter abnormitatem sive laesionem notam sive suspectam fetus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 51066 51066 -
Only index persons 50630 50630 -
Unadjusted period prevalence (%)
Whole population 1.46 1.46 -
Only index persons 1.86 1.86 -
Median age at first event (years)
Whole population - 32.35 -
Only index persons - 32.33 -

-FinnGen-

Key figures

All Female Male
Number of individuals 6237 6237 -
Unadjusted period prevalence (%) 2.45 2.45 -
Median age at first event (years) 33.27 33.27 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_MATERN_CARE_FETAL_ABNORM and mortality.

Females

Parameter HR [95% CI] p-value
O15_MATERN_CARE_FETAL_ABNORM 0.811 [0.7, 0.94] 0.005
Birth year 0.997 [0.99, 1.01] 0.548

During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 46555 females with O15_MATERN_CARE_FETAL_ABNORM died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_MATERN_CARE_FETAL_ABNORM.

N-year risk Females Males
1 0.066% No data
5 0.575% No data
10 1.281% No data
15 2.418% No data
20 4.469% No data

Relationships between endpoints

Index endpoint: O15_MATERN_CARE_FETAL_ABNORM – Maternal care for known or suspected fetal abnormality and damage

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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