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Other disorders of amniotic fluid and membranes

DOID EFO Endpoint Browser PheWeb

O15_AMNIOT_OTHER

oligohydramnios: A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O41
  • Hospital discharge: ICD-9 — 658
  • Hospital discharge: excluded ICD-9 — 6581A
  • Cause of death: ICD-10 — O41
  • Cause of death: ICD-9 — 658
  • Cause of death: excluded ICD-9 — 6581A

2 out of 7 registries used, show all original rules.

5654

4. Check minimum number of events

None

5654

5. Include endpoints

None

5654

6. Filter based on genotype QC (FinnGen only)

5413

Control definitions (FinnGen only)

Control exclude O15_MATERN_CARE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O30-O48
Name in latin Aliae morbositates liquoris amniotici et membranarum fetalium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 44809 44809 -
Only index persons 44328 44328 -
Unadjusted period prevalence (%)
Whole population 1.28 1.28 -
Only index persons 1.63 1.63 -
Median age at first event (years)
Whole population - 29.82 -
Only index persons - 29.81 -

-FinnGen-

Key figures

All Female Male
Number of individuals 5413 5413 -
Unadjusted period prevalence (%) 2.13 2.13 -
Median age at first event (years) 30.35 30.35 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_AMNIOT_OTHER and mortality.

Females

Parameter HR [95% CI] p-value
O15_AMNIOT_OTHER 0.705 [0.58, 0.85] < 0.001
Birth year 0.995 [0.99, 1.0] 0.25

During the follow-up period (1.1.1998 — 31.12.2019), 170 out of 32824 females with O15_AMNIOT_OTHER died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_AMNIOT_OTHER.

N-year risk Females Males
1 0.071% No data
5 0.365% No data
10 0.979% No data
15 1.92% No data
20 3.503% No data

Relationships between endpoints

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Index endpoint: O15_AMNIOT_OTHER – Other disorders of amniotic fluid and membranes

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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