psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
11495 |
4. Check minimum number of eventsNone |
11495 |
5. Include endpoints |
11965 |
6. Filter based on genotype QC (FinnGen only) |
11479 |
Control definitions (FinnGen only)
Control exclude
L12_PAPULOSQUAMOUS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40-L45
Name in latin
Psoriasis
Similar endpoints
↥List of similar endpoints to
Psoriasis
based on the number of shared cases.
Similar with more cases:
- Papulosquamous disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 86247 | 41718 | 43977 |
| Only index persons | 78371 | 38990 | 39381 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.21 | 1.19 | 1.23 |
| Only index persons | 1.47 | 1.43 | 1.50 |
| Median age at first event (years) | |||
| Whole population | 50.13 | 51.32 | 48.96 |
| Only index persons | 49.42 | 50.73 | 48.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11479 | 6069 | 5410 |
| Unadjusted period prevalence (%) | 2.54 | 2.38 | 2.72 |
| Median age at first event (years) | 51.39 | 50.73 | 52.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PSORIASIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORIASIS | 1.355 [1.24, 1.48] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 3798 out of 32117 females with L12_PSORIASIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORIASIS | 1.643 [1.51, 1.79] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5782 out of 32694 males with L12_PSORIASIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PSORIASIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.224% |
| 5 | 0.726% | 1.604% |
| 10 | 1.999% | 3.926% |
| 15 | 3.677% | 7.445% |
| 20 | 6.21% | 12.45% |
Relationships between endpoints
↥Index endpoint: L12_PSORIASIS – Psoriasis
GWS hits: 41
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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