psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
7456 |
4. Check minimum number of eventsNone |
7456 |
5. Include endpointsNone |
7456 |
6. Filter based on genotype QC (FinnGen only) |
7143 |
Control definitions (FinnGen only)
Control exclude
L12_PAPULOSQUAMOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40
Name in latin
Psoriasis vulgaris
Similar endpoints
↥List of similar endpoints to
Psoriasis vulgaris
based on the number of shared cases.
Similar with more cases:
- Psoriasis
- Papulosquamous disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 54747 | 24396 | 30005 |
| Only index persons | 50019 | 22879 | 27140 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.77 | 0.70 | 0.84 |
| Only index persons | 0.95 | 0.84 | 1.04 |
| Median age at first event (years) | |||
| Whole population | 51.19 | 52.17 | 50.35 |
| Only index persons | 50.44 | 51.58 | 49.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7143 | 3444 | 3699 |
| Unadjusted period prevalence (%) | 1.61 | 1.35 | 1.86 |
| Median age at first event (years) | 52.65 | 51.52 | 53.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PSORI_VULG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORI_VULG | 1.432 [1.3, 1.57] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.3 |
During the follow-up period (1.1.1998 — 31.12.2019), 2644 out of 20047 females with L12_PSORI_VULG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORI_VULG | 1.71 [1.57, 1.86] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 4660 out of 24237 males with L12_PSORI_VULG died.
Mortality risk
Mortality risk for people of age
years, who have L12_PSORI_VULG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.312% |
| 5 | 0.84% | 1.751% |
| 10 | 1.978% | 4.708% |
| 15 | 3.966% | 9.022% |
| 20 | 7.083% | 14.665% |
Relationships between endpoints
↥Index endpoint: L12_PSORI_VULG – Psoriasis vulgaris
GWS hits: 28
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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