No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
16337 |
4. Check minimum number of eventsNone |
16337 |
5. Include endpoints |
16985 |
6. Filter based on genotype QC (FinnGen only) |
16313 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Papulosquamous disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 122881 | 64322 | 57830 |
| Only index persons | 112392 | 60330 | 52062 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.73 | 1.84 | 1.62 |
| Only index persons | 2.11 | 2.22 | 1.99 |
| Median age at first event (years) | |||
| Whole population | 51.69 | 53.58 | 49.58 |
| Only index persons | 51.21 | 53.19 | 48.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16313 | 9204 | 7109 |
| Unadjusted period prevalence (%) | 3.60 | 3.61 | 3.57 |
| Median age at first event (years) | 53.20 | 53.11 | 53.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PAPULOSQUAMOUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PAPULOSQUAMOUS | 1.101 [1.01, 1.2] | 0.023 |
| Birth year | 0.995 [0.99, 1.0] | 0.225 |
During the follow-up period (1.1.1998 — 31.12.2019), 6193 out of 50607 females with L12_PAPULOSQUAMOUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PAPULOSQUAMOUS | 1.316 [1.21, 1.43] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 7476 out of 43774 males with L12_PAPULOSQUAMOUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PAPULOSQUAMOUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.273% |
| 5 | 0.644% | 1.657% |
| 10 | 1.635% | 4.056% |
| 15 | 3.243% | 7.516% |
| 20 | 5.66% | 13.074% |
Relationships between endpoints
↥Index endpoint: L12_PAPULOSQUAMOUS – Papulosquamous disorders
GWS hits: 37
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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