psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2249 |
4. Check minimum number of eventsNone |
2249 |
5. Include endpointsNone |
2249 |
6. Filter based on genotype QC (FinnGen only) |
2167 |
Control definitions (FinnGen only)
Control exclude
L12_PAPULOSQUAMOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified psoriasis
based on the number of shared cases.
Similar with more cases:
- Psoriasis
- Papulosquamous disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17507 | 7898 | 9423 |
| Only index persons | 14685 | 6954 | 7731 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.23 | 0.26 |
| Only index persons | 0.28 | 0.26 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 50.61 | 51.59 | 49.78 |
| Only index persons | 49.46 | 50.13 | 48.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2167 | 1068 | 1099 |
| Unadjusted period prevalence (%) | 0.49 | 0.42 | 0.55 |
| Median age at first event (years) | 50.91 | 49.47 | 52.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PSORI_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORI_NAS | 1.614 [1.41, 1.85] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.201 |
During the follow-up period (1.1.1998 — 31.12.2019), 797 out of 4508 females with L12_PSORI_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORI_NAS | 2.294 [2.01, 2.61] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1294 out of 5256 males with L12_PSORI_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PSORI_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.417% |
| 5 | 0.863% | 2.543% |
| 10 | 2.182% | 6.287% |
| 15 | 4.563% | 11.503% |
| 20 | 8.04% | 18.71% |
Relationships between endpoints
↥Index endpoint: L12_PSORI_NAS – Other and unspecified psoriasis
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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