parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
347 |
4. Check minimum number of eventsNone |
347 |
5. Include endpoints |
635 |
6. Filter based on genotype QC (FinnGen only) |
610 |
Control definitions (FinnGen only)
Control exclude
L12_PAPULOSQUAMOUS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40-L45
Name in latin
Parapsoriasis
Similar endpoints
↥List of similar endpoints to
Parapsoriasis
based on the number of shared cases.
Similar with more cases:
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5761 | 2864 | 2860 |
| Only index persons | 5168 | 2640 | 2528 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 41.07 | 38.49 | 43.65 |
| Only index persons | 39.87 | 37.84 | 41.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 610 | 328 | 282 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.14 |
| Median age at first event (years) | 48.04 | 42.17 | 54.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PARAPSORI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PARAPSORI | 1.115 [0.94, 1.32] | 0.2 |
| Birth year | 0.997 [0.99, 1.01] | 0.585 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 2204 females with L12_PARAPSORI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PARAPSORI | 0.996 [0.87, 1.14] | 0.949 |
| Birth year | 0.988 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 354 out of 2069 males with L12_PARAPSORI died.
Mortality risk
Mortality risk for people of age
years, who have L12_PARAPSORI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.203% |
| 5 | 0.617% | 1.12% |
| 10 | 1.461% | 2.943% |
| 15 | 2.779% | 5.843% |
| 20 | 5.352% | 10.016% |
Relationships between endpoints
↥Index endpoint: L12_PARAPSORI – Parapsoriasis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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