Pityriasis lichenoides chronica

L12_PARAPSO_PITYLICHCHRON

parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L41.1
  • Hospital discharge: ICD-9 6962B
  • Cause of death: ICD-10 L41.1
  • Cause of death: ICD-9 6962B

2 out of 7 registries used, show all original rules.

126

4. Check minimum number of events

None

126

5. Include endpoints

None

126

6. Filter based on genotype QC (FinnGen only)

122

Control definitions (FinnGen only)

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L41
Name in latin Pityriasis lichenoides chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1094 573 516
Only index persons 1012 541 471
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 47.37 51.09 43.22
Only index persons 46.68 50.15 42.71

-FinnGen-

Key figures

All Female Male
Number of individuals 122 62 60
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 55.01 52.78 57.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint L12_PARAPSO_PITYLICHCHRON and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
L12_PARAPSO_PITYLICHCHRON 1.103 [0.81, 1.5] 0.535
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 434 males with L12_PARAPSO_PITYLICHCHRON died.

Mortality risk

Mortality risk for people of age

years, who have L12_PARAPSO_PITYLICHCHRON.

N-year risk Females Males
1 No data 0.262%
5 No data 1.381%
10 No data 3.296%
15 No data 5.941%
20 No data 10.029%

Relationships between endpoints

Index endpoint: L12_PARAPSO_PITYLICHCHRON – Pityriasis lichenoides chronica

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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