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Pityriasis rosea

DOID EFO Endpoint Browser PheWeb

L12_PITYROCHEA

pityriasis rosea: a skin rash. It is benign but may inflict substantial discomfort in certain cases.Classically, it begins with a single "herald patch" lesion, followed in 1 or 2 weeks by a generalized body rash lasting up to 12 weeks, however usually around 6 - 8.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L42
  • Hospital discharge: ICD-9 — 6963
  • Hospital discharge: ICD-8 — 6963
  • Cause of death: ICD-10 — L42
  • Cause of death: ICD-9 — 6963
  • Cause of death: ICD-8 — 6963

2 out of 7 registries used, show all original rules.

255

4. Check minimum number of events

None

255

5. Include endpoints

None

255

6. Filter based on genotype QC (FinnGen only)

242

Control definitions (FinnGen only)

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L40-L45
Name in latin Pityriasis rosea

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2464 1398 1053
Only index persons 2221 1287 934
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 25.89 28.71 22.08
Only index persons 25.96 28.92 21.89

-FinnGen-

Key figures

All Female Male
Number of individuals 242 175 67
Unadjusted period prevalence (%) 0.06 0.07 0.03
Median age at first event (years) 33.39 33.30 33.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_PITYROCHEA and mortality.

Females

Parameter HR [95% CI] p-value
L12_PITYROCHEA 1.391 [0.95, 2.03] 0.087
Birth year 0.995 [0.99, 1.0] 0.267

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1019 females with L12_PITYROCHEA died.

Males

Parameter HR [95% CI] p-value
L12_PITYROCHEA 1.467 [1.09, 1.98] 0.013
Birth year 0.985 [0.97, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 650 males with L12_PITYROCHEA died.

Mortality risk

Mortality risk for people of age

years, who have L12_PITYROCHEA.

N-year risk Females Males
1 0.126% 0.239%
5 0.803% 1.615%
10 1.998% 3.935%
15 3.847% 7.278%
20 6.646% 12.309%

Relationships between endpoints

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Index endpoint: L12_PITYROCHEA – Pityriasis rosea

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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