psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
7456 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
1003 |
4. Check minimum number of eventsNone |
1003 |
5. Include endpointsNone |
1003 |
6. Filter based on genotype QC (FinnGen only) |
965 |
Control definitions (FinnGen only)
Control exclude
L12_PAPULOSQUAMOUS
Control conditions
not L12_PSORI_VULG
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Psoriasis (vulgaris), strict definition
based on the number of shared cases.
Similar with more cases:
- Psoriasis vulgaris
- Psoriasis
- Papulosquamous disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4808 | 1617 | 3168 |
| Only index persons | 4482 | 1538 | 2944 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.05 | 0.09 |
| Only index persons | 0.09 | 0.06 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 51.67 | 54.18 | 50.42 |
| Only index persons | 51.17 | 53.78 | 49.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 965 | 372 | 593 |
| Unadjusted period prevalence (%) | 0.24 | 0.15 | 0.30 |
| Median age at first event (years) | 51.50 | 53.06 | 50.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PSORI_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PSORI_STRICT | 1.781 [1.33, 2.39] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 1071 females with PSORI_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PSORI_STRICT | 1.697 [1.39, 2.07] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 2080 males with PSORI_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have PSORI_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.38% |
| 5 | 1.044% | 2.072% |
| 10 | 2.618% | 5.097% |
| 15 | 5.037% | 10.192% |
| 20 | 8.678% | 17.05% |
Relationships between endpoints
↥Index endpoint: PSORI_STRICT – Psoriasis (vulgaris), strict definition
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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